(Published 16 December 2014)Cite this as:BMJ2014;349:g7257
Weight we want to “lose”
Excess carbohydrate or protein in the diet is converted to triglyceride and stored in the lipid droplets of adipocytes. Excess dietary fat needs no conversion other than lipolysis and re-esterification. People who wish to lose weight while maintaining their fat-free mass are, biochemically speaking, attempting to metabolise the triglycerides stored in their adipocytes.
The chemical formula for an average triglyceride molecule can be deduced from fatty acid composition studies. In 1960, Hirsch and colleagues published data that yield an “average fatty acid” with the formula C17.4H33.1O2.1 This 50 year old result is in remarkable agreement with more recent data.2 Three “average fatty acids” esterified to the glycerol backbone (+3C, +6H) give an “average triglyceride” with the formula C54.8H104.4O6. The three most common fatty acids stored in human adipose tissues are oleate (C18H34O2), palmitate (C16H32O2), and linoleate (C18H32O2),12 which all esterify to form C55H104O6.
The complete oxidation of a single triglyceride molecule involves many enzymes and biochemical steps, but the entire process can be summarised as:
Ruben’s novel approach to the biochemistry of weight loss was to trace every atom in the fat being lost and, as far as I am aware, his results are completely new to the field,” says Professor Brown.
“He has also exposed a completely unexpected black hole in the understanding of weight loss amongst the general public and health professionals alike.”
If you follow the atoms in 10 kilograms of fat as they are ‘lost’, 8.4 of those kilograms are exhaled as carbon dioxide through the lungs. The remaining 1.6 kilograms becomes water, which may be excreted in urine, faeces, sweat, breath, tears and other bodily fluids, the authors report.
“None of this is obvious to people because the carbon dioxide gas we exhale is invisible,” says Mr Meerman. (Bold added for the media who depict CO2 as dark soot)
So, in the mind of this fairly unscientific blogger, if you lose 10g of ugly fat, you create the ingredients for photosynthesis: you create plant food.
So Lose weight and green the planet! WOW!
But wait! There's more.
Note that, from the top Figure, 10 grams of fat converts to 55 CO2 and only 52 H2O. As photosynthesis uses equal CO2 and H2O, therefore we have a surplus of 3 CO2.
What is Carboxtherapy? Carboxytherapy is a non-surgical procedure used to infuse CO2 gas below the skin. Carbox? Carbon and Oxygen or CO2.
Carboxytherapy works in two different ways: it first fragilizes fat cells with a pressure traumatism, then, in second, CO2 leads to flood vassels dilation in the area where the gas is injected. This reaction to carbon dioxide injection gives a better oxygenation of skin layers with increased lipolysis capabilities. The end result is fewer fat cells and skin tightening.
So, it's a bit like perpetual motion. You lose weight, exhale CO2, inject the excess CO2 and lose more weight.